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Other 19th-century discoveries in chemistry included the world's first synthetic fertilizer, manufactured in England in 1842. In 1846 German chemist Christian Schoenbein accidentally developed the powerful and unstable explosive nitrocellulose. The discovery occurred after he had spilled a mixture of nitric and sulfuric acids and then mopped it up with a cotton apron. After the apron had been hung up to dry, it exploded. He later learned that the cellulose in the cotton apron combined with the acids to form a highly flammable explosive.


In 1828 the German chemist Friedrich Wöhler showed that it was possible to make carbon-containing, organic compounds from inorganic ingredients, a breakthrough that opened up an entirely new field of research. By the end of the 19th century, hundreds of organic compounds had been synthesized, including mauve, magenta, and other synthetic dyes, as well as aspirin, still one of the world's most useful drugs.

In physics, the 19th century is remembered chiefly for research into electricity and magnetism, which were pioneered by physicists such as Michael Faraday and James Clerk Maxwell of Great Britain. In 1821 Faraday demonstrated that a moving magnet could set an electric current flowing in a conductor. This experiment and others he performed led to the development of electric motors and generators. While Faraday’s genius lay in discovery by experiment, Maxwell produced theoretical breakthroughs of even greater note. Maxwell's famous equations, devised in 1864, uses mathematics to explain the interactions between electric and magnetic fields. His work demonstrated the principles behind electromagnetic waves, created when electric and magnetic fields oscillate simultaneously. Maxwell realized that light was a form of electromagnetic energy, but he also thought that the complete electromagnetic spectrum must include many other forms of waves as well. With the discovery of radio waves by German physicist Heinrich Hertz in 1888 and X rays by German physicist Wilhelm Roentgen in 1895, Maxwell’s ideas were proved correct. In 1897 British physicist Sir Joseph J. Thomson discovered the electron, a subatomic particle with a negative charge. This discovery countered the long - head notion that atoms were the basic unit of matter.

As in chemistry, these 19th-century discoveries in physics proved to have immense practical value. No one was more adept at harnessing them than American physicist and prolific inventor Thomas Edison. Working from his laboratories in Menlo Park, New Jersey, Edison devised the carbon-granule microphone in 1877, which greatly improved the recently invented telephone. He also invented the phonograph, the electric light bulb, several kinds of batteries, and the electric metre. Edison was granted more than 1,000 patents for electrical devices, a phenomenal feat for a man who had no formal schooling.

In the earth sciences, the 19th century was a time of controversy, with scientists debating Earth's age. Estimates ranged from less than 100,000 years to several hundred million years. In astronomy, greatly improved optical instruments enabled important discoveries to be made. The first observation of an asteroid, Ceres, took place in 1801. Astronomers had long noticed that Uranus exhibited an unusual orbit. French astronomer Urbain Jean Joseph Leverrier predicted that another planet nearby caused Uranus’s odd orbit. Using mathematical calculations, he narrowed down where such a planet would be located in the sky. In 1846, with the help of German astronomer Johann Galle, Leverrier discovered Neptune. The Irish astronomer William Parsons, the third Earl of Rosse, became the first person to see the spiral form of galaxies beyond our own solar system. He did this with the Leviathan, a 183-cm (72-in) reflecting telescope, built on the grounds of his estate in Parsonstown (now Birr), Ireland, in the 1840s. His observations were hampered by Ireland's damp and cloudy climate, but his gigantic telescope remained the world's largest for more than 70 years.

In the 19th century the study of microorganisms became increasingly important, particularly after French biologist Louis Pasteur revolutionized medicine by correctly deducing that some microorganisms are involved in disease. In the 1880's Pasteur devised methods of immunizing people against diseases by deliberately treating them with weakened forms of the disease-causing organisms themselves. Pasteur’s vaccine against rabies was a milestone in the field of immunization, one of the most effective forms of preventive medicine the world has yet seen. In the area of industrial science, Pasteur invented the process of pasteurization to help prevent the spread of disease through milk and other foods.

Also during the 19th century, the Austrian monk Gregor Mendel laid the foundations of genetics, although his work, published in 1866, was not recognized until after the century had closed. But the British scientist Charles Darwin towers above all other scientists of the 19th century. His publication of On the Origin of Species in 1859 marked a major turning point for both biology and human thought. His theory of evolution by natural selection (independently and simultaneously developed by British naturalist Alfred Russel Wallace) initiated a violent controversy that still has not subsided. Particularly controversial was Darwin’s theory that humans resulted from a long process of biological evolution from apelike ancestors. The greatest opposition to Darwin’s ideas came from those who believed that the Bible was an exact and literal statement of the origin of the world and of humans. Although the public initially castigated Darwin’s ideas, by the late 1800s most biologists had accepted that evolution occurred, although not all agreed on the mechanism, known as natural selection, that Darwin proposed.

In the 20th century, scientists achieved spectacular advances in the fields of genetics, medicine, social sciences, technology, and physics.


At the beginning of the 20th century, the life sciences entered a period of rapid progress. Mendel's work in genetics was rediscovered in 1900, and by 1910 biologists had become convinced that genes are located in chromosomes, the threadlike structures that contain proteins and deoxyribonucleic acid (DNA). During the 1940s American biochemists discovered that DNA taken from one kind of bacterium could influence the characteristics of another. From these experiments, it became clear that DNA is the chemical that makes up genes and thus the key to heredity.

After American biochemist James Watson and British biophysicist Francis Crick established the structure of DNA in 1953, geneticists became able to understand heredity in chemical terms. Since then, progress in this field has been astounding. Scientists have identified the complete genome, or genetic catalogue, of the human body. In many cases, scientists now know how individual genes become activated and what affects they have in the human body. Genes can now be transferred from one species to another, side - stepping the normal processes of heredity and creating hybrid organisms that are unknown in the natural world.

At the turn of the 20th century, Dutch physician Christian Eijkman showed that disease can be caused not only by microorganisms but by a dietary deficiency of certain substances now called vitamins. In 1909 German bacteriologist Paul Ehrlich introduced the world's first bactericide, a chemical designed to kill specific kinds of bacteria without killing the patient's cells as well. Following the discovery of penicillin in 1928 by British bacteriologist Sir Alexander Fleming, antibiotics joined medicine’s chemical armoury, making the fight against bacterial infection almost a routine matter. Antibiotics cannot act against viruses, but vaccines have been used to great effect to prevent some of the deadliest viral diseases. Smallpox, once a worldwide killer, was completely eradicated by the late 1970's, and in the United States the number of polio cases dropped from 38,000 in the 1950's to less than 10 a year by the 21st century.

By the middle of the 20th century scientists believed they were well on the way to treating, preventing, or eradicating many of the most deadly infectious diseases that had plagued humankind for centuries. But by the 1980s the medical community’s confidence in its ability to control infectious diseases had been shaken by the emergence of new types of disease-causing microorganisms. New cases of tuberculosis developed, caused by bacteria strains that were resistant to antibiotics. New, deadly infections for which there was no known cure also appeared, including the viruses that cause hemorrhagic fever and the human immunodeficiency virus (HIV), the cause of acquired immunodeficiency syndrome.

In other fields of medicine, the diagnosis of disease has been revolutionized by the use of new imaging techniques, including magnetic resonance imaging and computed tomography. Scientists were also on the verge of success in curing some diseases using gene therapy, in which the insertions of normal or genetically altered genes into a patient’s cells replace nonfunctional or missing genes.

Improved drugs and new tools have made surgical operations that were once considered impossible now routine. For instance, drugs that suppress the immune system enable the transplant of organs or tissues with a reduced risk of rejection. Endoscopy permits the diagnosis and surgical treatment of a wide variety of ailments using minimally invasive surgery. Advances in high - speed fibreoptic connections permit surgery on a patient using robotic instruments controlled by surgeons at another location. Known as telemedicine, this form of medicine makes it possible for skilled physicians to treat patients in remote locations or places that lack medical help.

In the 20th century the social sciences emerged from relative obscurity to become prominent fields of research. Austrian physician Sigmund Freud founded the practice of psychoanalysis, creating a revolution in psychology that led him to be called the ‘Copernicus of the mind.’ In 1948 the American biologist Alfred Kinsey published Sexual Behaviour in the Human Male, which proved to be one of the best - selling scientific works of all time. Although criticized for his methodology and conclusions, Kinsey succeeded in making human sexuality an acceptable subject for scientific research.

The 20th century also brought dramatic discoveries in the field of anthropology, with new fossil finds helping to piece together the story of human evolution. A completely new and surprising source of anthropological information became available from studies of the DNA in mitochondria, cell structures that provide energy to fuel the cell’s activities. Mitochondrial DNA has been used to track certain genetic diseases and to trace the ancestry of a variety of organisms, including humans.

In the field of communications, Italian electrical engineer Guglielmo Marconi sent his first radio signal across the Atlantic Ocean in 1901. American inventor Lee De Forest invented the triode, or vacuum tube, in 1906. The triode eventually became a key component in nearly all early radio, radar, television, and computer systems. In 1920 Scottish engineer John Logie Baird developed the Baird Televisor, a primitive television that provided the first transmission of a recognizable moving image. In the 1920's and 1930's American electronic engineer Vladimir Kosma Zworykin significantly improved the television’s picture and reception. In 1935 British physicist Sir Robert Watson-Watt used reflected radio waves to locate aircraft in flight. Radar signals have since been reflected from the Moon, planets, and stars to learn their distance from Earth and to track their movements.

In 1947 American physicists John Bardeen, Walter Brattain, and William Shockley invented the transistor, an electronic device used to control or amplify an electrical current. Transistors are much smaller, far less expensive, require less power to operate, and are considerably more reliable than triodes. Since their first commercial use in hearing aids in 1952, transistors have replaced triodes in virtually all applications.

During the 1950's and early 1960's minicomputers were developed using transistors rather than triodes. Earlier computers, such as the electronic numerical integrator and computer (ENIAC), first introduced in 1946 by American physicist John W. Mauchly and American electrical engineer John Presper Eckert, Jr., used as many as 18,000 triodes and filled a large room. But the transistor initiated a trend toward microminiaturization, in which individual electronic circuits can be reduced to microscopic size. This drastically reduced the computer's size, cost, and power requirements and eventually enabled the development of electronic circuits with processing speeds measured in billionths of a second.

Further miniaturization led in 1971 to the first microprocessor - a computer on a chip. When combined with other specialized chips, the microprocessor becomes the central arithmetic and logic unit of a computer smaller than a portable typewriter. With their small size and a price less than that of a used car, today’s personal computers are many times more powerful than the physically huge, multimillion-dollar computers of the 1950’s. Once used only by large businesses, computers are now used by professionals, small retailers, and students to perform a wide variety of everyday tasks, such as keeping data on clients, tracking budgets, and writing school reports. People also use computers to interface with worldwide communications networks, such as the Internet and the World Wide Web, to send and receive E - mail, to shop, or to find information on just about any subject.

During the early 1950's public interest in space exploration developed. The focal event that opened the space age was the International Geophysical Year from July 1957 to December 1958, during which hundreds of scientists around the world coordinated their efforts to measure the Earth’s near-space environment. As part of this study, both the United States and the Soviet Union announced that they would launch artificial satellites into orbit for nonmilitary space activities.

When the Soviet Union launched the first Sputnik satellite in 1957, the feat spurred the United States to intensify its own space exploration efforts. In 1958 the National Aeronautics and Space Administration (NASA) was founded for the purpose of developing human spaceflight. Throughout the 1960s NASA experienced its greatest growth. Among its achievements, NASA designed, manufactured, tested, and eventually used the Saturn rocket and the Apollo spacecraft for the first manned landing on the Moon in 1969. In the 1960s and 1970's, NASA also developed the first robotic space probes to explore the planet’s Mercury, Venus, and Mars. The success of the Mariner probes paved the way for the unmanned exploration of the outer planets in Earth’s solar system.

In the 1970's through 1990's, NASA focussed its space exploration efforts on a reusable space shuttle, which was first deployed in 1981. In 1998 the space shuttle, along with its Russian counterpart known as Soyuz, became the workhorses that enabled the construction of the International Space Station.

In 1900 the German physicist Max Planck proposed the then sensational idea that energy be not divisible but is always given off in set amounts, or quanta. Five years later, German-born American physicist Albert Einstein successfully used quanta to explain the photoelectric effect, which is the release of electrons when metals are bombarded by light. This, together with Einstein's special and general theories of relativity, challenged some of the most fundamental assumptions of the Newtonian era.

Unlike the laws of classical physics, quantum theory deals with events that occur on the smallest of scales. Quantum theory explains how subatomic particles form atoms, and how atoms interact when they combine to form chemical compounds. Quantum theory deals with a world where the attributes of any single particle can never be completely known - an idea known as the uncertainty principle, put forward by the German physicist Werner Heisenberg in 1927. But while there is uncertainty on the subatomic level, quantum physics successfully predicts the overall outcome of subatomic events, a fact that firmly relates it to the macroscopic world - that is, the one in which we live.

In 1934 Italian-born American physicist Enrico Fermi began a series of experiments in which he used neutrons (subatomic particles without an electric charge) to bombard atoms of various elements, including uranium. The neutrons combined with the nuclei of the uranium atoms to produce what he thought were elements heavier than uranium, known as transuranium elements. In 1939 other scientists demonstrated that in these experiments’ Fermi had not formed heavier elements, but instead had achieved the splitting, or fission, of the uranium atom's nucleus. These early experiments led to the development of fission as both an energy source and a weapon.

These fission studies, coupled with the development of particle accelerators in the 1950's, initiated a long and remarkable journey into the nature of subatomic particles that continues today. Far from being indivisible, scientists now know that atoms are made up of 12 fundamental particles known as quarks and leptons, which combine in different ways to make all the kinds of matter currently known.

Advances in particle physics have been closely linked to progress in cosmology. From the 1920's onward, when the American astronomer Edwin Hubble showed that the universe is expanding, cosmologists have sought to rewind the clock and establish how the universe began. Today, most scientists believe that the universe started with a cosmic explosion some time between 10 and 20 billion years ago.  However, the exact sequence of events surrounding its birth, and its ultimate fate, are still matters of ongoing debate.

Particle Accelerators, in physics, are the devices used to accelerate charged elementary particles or ions to high energies. Particle accelerators today are some of the largest and most expensive instruments used by physicists. They all have the same three basic parts: a source of elementary particles or ions, a tube pumped to a partial vacuum in which the particles can travel freely, and some means of speeding up the particles.

Charged particles can be accelerated by an electrostatic field. For example, by placing electrodes with a large potential difference at each end of an evacuated tube, British scientists’ John D. Cockcroft and Ernest Thomas Sinton Walton were able to accelerate protons to 250,000 eV. Another electrostatic accelerator is the Van de Graaff accelerator, which was developed in the early 1930's by the American physicist Robert Jemison Van de Graaff. This accelerator uses the same principles as the Van de Graaff Generator. The Van de Graaff accelerator builds up a potential between two electrodes by transporting charges on a moving belt. Modern Van de Graaff accelerators can accelerate particles to energies as high as 15 MeV (15 million electron volts).

Another machine, first conceived in the late 1920's, is the linear accelerator, or linac, which uses alternating voltages of high magnitude to push particles along in a straight line. Particles pass through a line of hollow metal tubes enclosed in an evacuated cylinder. An alternating voltage is timed so that a particle is pushed forward each time it goes through a gap between two of the metal tubes. Theoretically, a linac of any energy can be built. The largest linac in the world, at Stanford University, is 3.2 km. (2 mi.) long. It is capable of accelerating electrons to an energy of 50 GeV (50 billion, or giga, electron volts). Stanford's linac is designed to collide two beams of particles accelerated on different tracks of the accelerator.

The American physicist Ernest O. Lawrence won the 1939 Nobel Prize in physics for a breakthrough in accelerator design in the early 1930's. He developed the cyclotron, the first circular accelerator. A cyclotron is somewhat like a linac wrapped into a tight spiral. Instead of many tubes, the machine had only two hollow vacuum chambers, called dees, that are shaped like capital letter Ds back to back. A magnetic field, produced by a powerful electromagnet, keeps the particles moving in a circle. Each time the charged particles pass through the gap between the dees, they are accelerated. As the particles gain energy, they spiral out toward the edge of the accelerator until they gain enough energy to exit the accelerator. The world's most powerful cyclotron, the K1200, began operating in 1988 at the National Superconducting Cyclotron Laboratory at Michigan State University. The machine is capable of accelerating nuclei to an energy approaching 8 GeV.

When nuclear particles in a cyclotron gain an energy of 20 MeV or more, they become appreciably more massive, as predicted by the theory of relativity. This tends to slow them and throws the acceleration pulses at the gaps between the dees out of phase. A solution to this problem was suggested in 1945 by the Soviet physicist Vladimir I. Veksler and the American physicist Edwin M. McMillan. The solution, the synchrocyclotron, is sometimes called the frequency-modulated cyclotron. In this instrument, the oscillator (radio - frequency generator) that accelerates the particles around the dees is automatically adjusted to stay in step with the accelerated particles; as the particles gain mass, the frequency of accelerations is lowered slightly to keep in step with them. As the maximum energy of a synchrocyclotron increases, so must its size, for the particles must have more space in which to spiral. The largest synchrocyclotron is the 600-cm. (236-in.) phasotron at the Dubna Joint Institute for Nuclear Research in Russia; it accelerates protons to more than 700 MeV and has magnets weighing 6984 metric tons (7200 tons).

When electrons are accelerated, they undergo a large increase in mass at a relatively low energy. At 1 MeV energy, an electron weighs two and one - half times as much as an electron at rest. Synchrocyclotrons cannot be adapted to make allowance for such large increases in mass. Therefore, another type of cyclic accelerator, the betatron, is employed to accelerate electrons. The betatron consists of a doughnut-shaped evacuated chamber placed between the poles of an electromagnet. The electrons are kept in a circular path by a magnetic field called a guide field. By applying an alternating current to the electromagnet, the electromotive force induced by the changing magnetic flux through the circular orbit accelerates the electrons. During operation, both the guide field and the magnetic flux are varied to keep the radius of the orbit of the electrons constant.